At least 45 people have died in Israeli airstrikes in the Gaza Strip, where the conflict has now reached its 448th day. Among the casualties are five members of an Islamic movement-affiliated television crew and several hospital workers. Local health officials report worsening conditions, highlighting a grave humanitarian crisis as medical facilities are targeted and cold weather exacerbates suffering for displaced families. The Israeli military states its operations are aimed at disrupting Hamas forces, while the toll of the conflict continues to rise significantly on both sides.