A group of scientists has raised alarm about the potential risks associated with mirror bacteria—synthetic microbes that could evade natural defenses in humans, animals, and plants. These mirror bacteria are designed as structural reflections of natural microorganisms and could disrupt ecosystems, evade immune responses, and lead to uncontrollable infections. The scientists call for a global dialogue and stringent oversight, stressing that the risks far outweigh the potential benefits. Among the experts, there are Nobel laureates who emphasize the unprecedented threat posed by these engineered microorganisms.