On World AIDS Day, Yazdan Yazdanpanah, director of the French National Agency for Research on HIV, hepatitis, and emerging infectious diseases, announced efforts to achieve zero HIV transmission by 2030. While new HIV infections have stabilized since the COVID-19 pandemic, Yazdanpanah emphasizes the need for increased prevention and testing, particularly among vulnerable populations, including migrant communities in rural areas. Innovative treatments, such as an upcoming biannual injection, and existing prevention methods like PrEP are highlighted as key tools in the fight against HIV.